Requesting Sentieon licenses for private workflows - AWS HealthOmics

AWS HealthOmics variant stores and annotation stores will no longer be open to new customers starting November 7th, 2025. If you would like to use variant stores or annotation stores, sign up prior to that date. Existing customers can continue to use the service as normal. For more information, see AWS HealthOmics variant store and annotation store availability change.

Requesting Sentieon licenses for private workflows

If your private workflow uses Sentieon software, you need a Senieon license. Follow these steps to request and set up a license for the Sentieon software:

  • Request a Sentieon license

    • Send an email to the Sentieon support group (support@sentieon.com) to request a software license.

      • Provide your AWS Canonical User ID in the email.

      • Find your AWS Canonical User ID by following these instructions.

  • Update your HealthOmics service role to grant it access to the Sentieon licensing server proxy and Sentieon Omics bucket in your Region. The following example grants access in us-east-1. If required, replace this text with your Region.

    JSON
    {
           "Version":"2012-10-17",		 	 	 
    "Statement": [
        {
            "Effect": "Allow",
            "Action": [
                "s3:GetObjectAcl",
                "s3:GetObject"
            ],
            "Resource": [
                "arn:aws:s3:::omics-ap-us-east-1/*",
                "arn:aws:s3:::sentieon-omics-license-us-east-1/*"
            ]
        }
    ]
 }

  • Generate an AWS support case to get access to the Sentieon license server proxy.

  • Build your private workflow using the Sentieon container and the Sentieon license script.

    • For additional instructions on using Sentieon tools inside private workflows, see Sentieon-Amazon-Omics in GitHub.

  • Sentieon software version 202112.07 and higher support the HealthOmics licensing server proxy. To use Sentieon software versions earlier than 202112.07, contact Sentieon support.